목적: This meta-analysis aims to assess the effect of CPAP therapy on all- cause mortality in patients with obstructive sleep apnea (OSA). 방법:We systematically searched PubMed, Embase, and Scopus from inception through February 3, 2025, for randomized controlled or cohort studies reporting covariate-matched or adjusted survival curves for all-cause mortality among adults with OSA, comparing CPAP users and non-users. Individual patient survival data (IPD) was reconstructed using iterative numerical algorithms and pooled in a one-stage meta-analysis. Shared- frailty and stratified Cox models were fitted to obtain hazard ratios (HRs), taking into account study-level clustering of participants. A two-stage meta-analysis using a random-effects inverse variance model was performed as a sensitivity analysis. 결과:Of the 4,507 records screened, 6 studies (1,086,556 participants) were included. All studies matched participants by age, gender, and comorbidities. The one-stage IPD meta-analysis showed that CPAP users had a 44% lower risk of all-cause mortality compared to non-users (HR 0.56, 95% CI: 0.5550.565). Sensitivity analyses using stratified and marginal models yielded similar results. The two-stage meta-analysis also indicated a 44% reduction in mortality risk among CPAP users (HR 0.56, 95% CI: 0.520.61, I² = 83.2%). 결론:CPAP therapy is associated with a substantial reduction in all-cause mortality among patients with obstructive sleep apnea. These findings provide robust evidence supporting the effectiveness of CPAP in improving long-term survival and underscore its potential as a critical intervention for reducing mortality risk in this patient population.