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OBESITY AND ALLERGIC RHINITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF THEIR EPIDEMIOLOGICAL ASSOCIATION
DEP. OF OTORHINOLARYNGOLOGY©Ö, AIRLANGGA UNIV. COLLEGE OF MEDICINE, DEP. OF OTORHINOLARYNGOLOGY ©÷, DR. SOETOMO ACADEMIC GENERAL HOSP.
ELSA ROSALINA, ELSA ROSALINA 1,2, DWI R. PAWARTI 1,2
¸ñÀû: Obesity has been increasingly identified as a potential risk factor for allergic rhinitis (AR) due to its influence on inflammatory, metabolic, and immune pathways. However, inconsistencies in previous research necessitate a thorough assessment. This meta-analysis aims to evaluate the relationship between obesity and AR in both children and adults to clarify its clinical implications. ¹æ¹ý:A systematic review was conducted, incorporating both observational and interventional studies. Eligible studies examining obesity as a risk factor for AR were assessed using the Newcastle-Ottawa Scale (NOS) for cohort and case-control studies and the ROBINS-I tool for interventional studies. A random-effects meta-analysis was performed with RevMan 5.4.1, and heterogeneity was analyzed using the Q-statistic and I©÷ test. °á°ú:A total of 30 studies including 21,968,039 participants were analyzed. The pooled results revealed a significant association between obesity and AR (OR = 1.42, 95% CI: 1.18 1.71, p < 0.05), indicating that obese individuals have a higher likelihood of developing AR. Heterogeneity analysis suggested low variability among studies, reinforcing the consistency of the findings. °á·Ð:This meta-analysis provides compelling evidence that obesity is a key risk factor for AR, likely driven by chronic inflammation, metabolic imbalances, and immune dysregulation. These findings highlight the necessity of comprehensive weight management strategies in AR prevention and treatment. Future studies should focus on longitudinal and mechanistic investigations to establish causality and develop targeted interventions to reduce the risk of obesity-related AR.


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