¸ñÀû: Obesity has been increasingly identified as a potential risk factor for
allergic rhinitis (AR) due to its influence on inflammatory, metabolic,
and immune pathways. However, inconsistencies in previous research
necessitate a thorough assessment. This meta-analysis aims to evaluate
the relationship between obesity and AR in both children and adults to
clarify its clinical implications. ¹æ¹ý:A systematic review was conducted, incorporating both observational and
interventional studies. Eligible studies examining obesity as a risk
factor for AR were assessed using the Newcastle-Ottawa Scale (NOS) for
cohort and case-control studies and the ROBINS-I tool for interventional
studies. A random-effects meta-analysis was performed with RevMan 5.4.1,
and heterogeneity was analyzed using the Q-statistic and I©÷ test. °á°ú:A total of 30 studies including 21,968,039 participants were analyzed.
The pooled results revealed a significant association between obesity
and AR (OR = 1.42, 95% CI: 1.18 1.71, p < 0.05), indicating that obese
individuals have a higher likelihood of developing AR. Heterogeneity
analysis suggested low variability among studies, reinforcing the
consistency of the findings. °á·Ð:This meta-analysis provides compelling evidence that obesity is a key
risk factor for AR, likely driven by chronic inflammation, metabolic
imbalances, and immune dysregulation. These findings highlight the
necessity of comprehensive weight management strategies in AR
prevention and treatment. Future studies should focus on longitudinal
and mechanistic investigations to establish causality and develop
targeted interventions to reduce the risk of obesity-related AR. |