Myofibromas are uncommon tumors typically occurring in infants in the head and neck region. The spectrum of clinical behavior is broad, ranging from spontaneous regression to multi-visceral involvement and death. Though common in the head and neck, the occurrence of myofibroma in nasal septum is rare and its solitary occurrence in adult patients is even more rare. We present the case of a solitary adult-onset myofibroma of the nasal septum and discuss its differential diagnosis and pathologic findings. A 72-year-old man presented with recurrent right- sided epistaxis. Nasopharyngoscopy revealed a vascular mass in the right sphenoethmoidal recess. Paranasal CT and MRI suggested a hemangioma. During surgery, a small hemorrhagic mass was excised from the left posterior nasal septum, and histopathological examination confirmed the diagnosis of myofibroma. Postoperatively, the patient has been under follow-up with no signs of recurrence to date.