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PREVALENCE OF PATHOLOGIC DURAL INVASION IN EARLY-STAGE OLFACTORY NEUROBLASTOMA
DEPARTMENT OF OTORHINOLARYNGOLOGY-HEAD AND NECK SURGERY, NATIONAL MEDICAL CENTER©ö DEPARTMENT OF OTORHINOLARYNGOLOGY-HEAD AND NECK SURGERY, SEOUL NATIONAL UNIVERSITY COLLEGE OF MEDICINE, SEOUL NATIONAL UNIVERSITY BUNDANG HOSPITAL©÷ DEPARTMENT OF OTORHINOLARYNGOLOGY-HEAD AND NECK SURGERY, SEOUL NATIONAL UNIVERSITY COLLEGE OF MEDICINE, SEOUL NATIONAL UNIVERSITY HOSPITAL©ø
MINJU KIM, MINJU KIM©ö, SUNG-WOO CHO©÷, DOO HEE HAN©ø, HYUN JIK KIM©ø, JEONG-WHUN KIM©÷, DONG-YOUNG KIM©ø, CHAE-SEO RHEE©÷, TAE-BIN WON©ø
¸ñÀû: Dural invasion in olfactory neuroblastoma (ONB) is a key prognostic factor influencing recurrence and survival. However, its preoperative assessment can be challenging, particularly in early-stage cases. This study aims to evaluate the prevalence and associated factors of pathologic dural invasion in early-stage ONB. ¹æ¹ý:Patients diagnosed with ONB at two academic centers between 1992 and 2023 were retrospectively reviewed. Those with definitive evidence of dural or orbital invasion, cervical lymph node metastasis at presentation, or who did not undergo dural resection were excluded. Demographic and tumor characteristics, treatment modalities, recurrence patterns, and survival outcomes were analyzed using descriptive and time-to-event analyses. °á°ú:A total of 21 patients (14 males, 7 females) were included, with a mean age of 41.2 ¡¾ 13.2 years. The mean follow-up duration was 68.4 ¡¾ 56.8 months. Pathologic dural invasion was confirmed in 8 of 21 patients (38.1%). Overall survival (P = 0.339) and disease-free survival (P = 0.142) did not differ significantly between patients with and without pathologic dural invasion. °á·Ð:In cases where dural resection was performed, pathologic dural invasion was identified in 38.1% of early-stage ONB cases. However, in early-stage tumors, it may not significantly impact survival. A larger cohort study is needed to further elucidate optimal treatment strategies for early-stage ONB.


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