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COMPARATIVE STUDY OF CLICK-EVOKED AUDITORY BRAINSTEM RESPONSE VS AUDITORY STEADY-STATE RESPONSE HEARING THRESHOLDS - A SYSTEMATIC REVIEW AND META ANALYSIS
DEP. OF OTORHINOLARYNGOLOGY HEAD AND NECK SURGERY, GADJAH MADA UNIV.
MONIK ALAMANDA, MONIK ALAMANDA, ARIEF PURNANTA, AGUS SURONO
¸ñÀû: To compare the electrophysiologic hearing thresholds provided by Click-evoked Auditory Brainstem Response (c-ABR) and Auditory Steady-State Response (ASSR) across various frequencies in pediatric population. ¹æ¹ý:A systematic review was conducted using Google Scholar, ProQuest, PubMed, and ScienceDirect, focusing on correlation coefficients between c-ABR and ASSR thresholds across various frequencies. The review included 22 observational studies. Meta-analyses were conducted using random effects models, with subgroup analyses based on various factors. °á°ú:The overall correlations between c-ABR and ASSR thresholds were strong and significant across different ASSR frequencies. The random effects model indicated a correlation coefficient (COR) of 0.73 (95% CI: 0.21 to 0.93) at 1 kHz (4 studies), 0.83 (95% CI: 0.69 to 0.91) at 2 kHz (9 studies), 0.82 (95% CI: 0.71 to 0.89) at 4 kHz (9 studies), 0.84 (95% CI: 0.68 to 0.93) for 1-4 kHz (10 studies), and 0.84 (95% CI: 0.72 to 0.92) for 2-4 kHz (15 studies). Substantial heterogeneity was observed (I©÷: 86.2% - 97.1%). The high fail-safe N values suggested robustness against publication bias. Subgroup analyses revealed significant differences based on ABR instruments, while other factors such as countries, sample sizes, and publication dates did not show significant differences. ASSR stimuli of modulated tones provided stronger correlations with c-ABR thresholds compared to chirp stimuli. Despite this, ASSR notably lacks the ability to recognize Auditory Neuropathy Spectrum Disorder. °á·Ð:This systematic review and meta-analysis demonstrates that ASSR provides reliable frequency-specific information that correlates well with c-ABR thresholds, making it valuable for pediatric audiology. ASSRs limitation prompts clinicians to combine it with other audiological tests. The findings are particularly relevant for resource-limited settings, where ASSR can offer a practical solution for detailed hearing assessments. Despite high heterogeneity, the results are robust and highlight the need for further research to explore contributing factors.


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