목적: Acute invasive fungal rhinosinusitis (AIFRS) is a rare disease with high mortality. Multiple fungal organisms have been implicated, with mucormycosis postulated to cause the most aggressive disease. This study investigates fungal organisms in relation to underlying immunodeficiencies, socioeconomic factors, and patient outcomes. 방법:Retrospective review of 95 patients with AIFRS at UCLA between years 2010 and 2024. Logistic regression, ANOVA, Student t-test, and Cox regression were performed. 결과:Mucormycosis accounted for 63% of cases, Aspergillus 36%, and Candida 5%. 41% of the patients were female, 67% spoke English, 40% identified as white, 61% had diabetes, 48% were on immunosuppressants, 17% had a transplant, 15% had liver disease, and 11% had chronic/end-stage renal disease. Following management, 22% were alive without neurologic deficits, 22% were alive with neurologic deficits, 51% were deceased, and 5% were lost to follow-up. HbA1c levels correlated significantly with mucormycosis (p = 0.009, OR 1.6) and Aspergillus (p = 0.019, OR 0.69). Average HgbA1c of mucormycosis, Aspergillus, Candida, and no fungal isolate were 10.1, 7.8, 7.6, 5.9, respectively. There were no correlations between fungal organism and patient outcomes. History of transplant, however, portended to increased odds of mortality (p = 0.023, OR 19.2). There were no significant correlations between survival and fungal organism, time to treatment, hospitalization duration or transfer, intracranial/ocular involvement, and immunodeficiencies aside from transplant history. Majority (92%) of AIFRS-related deaths occurred within 3 months of symptom development. 결론:Causative fungal organisms were differentially correlated with HgbA1c levels. However, organisms demonstrated no correlation with socioeconomic factors nor prognosis. History of organ transplant portended significantly greater mortality. Majority of AIFRS-related deaths occurred within the first 3 months of symptom development. These findings suggest severity of underlying immunodeficiencies may influence predilection for organisms and clinical outcomes through differing mechanisms.