¸ñÀû: The major typical types of benign paroxysmal positional vertigo (BPPV)
include posterior canal canalolithiasis (PC-BPPV), horizontal canal
canalolithiasis and cupulolithiasis (HC-BPPV), and anterior canal
canalolithiasis (AC-BPPV). We defined atypical BPPV as cases where the
clinical presentation does not align with the established criteria for
typical subtypes or where symptoms and nystagmus persist despite
repeated canalith repositioning therapy (CRT). We evaluated the
clinical course and vitamin D levels in individuals diagnosed with
atypical BPPV compared to those with typical BPPV. ¹æ¹ý:We investigated the clinical courses (number of previous BPPV diagnoses,
the intensity of nystagmus at the initial visit, number of CRT treatment
failures, the time to symptom resolution, and the persistence of
untreated nystagmus in the patients). Vitamin D levels were measured at
the time of the first visit for symptoms. °á°ú:Among a total of 55 patients, 30 were diagnosed with typical BPPV
(mean age: 56.9 years, 21 females), while 25 were identified as having
atypical BPPV (mean age: 56.9 years, 13 females). Atypical BPPV
presented in various forms, including cases with heavy cupula or light
cupula of HC (n=11), cupulolithiasis of PC-BPPV (n=7), apogeotropic
PC-BPPV (n=1), symptoms and nystagmus unresolved after repeated CRT
sessions with undefined positional nystagmus (n=6).
The number of previous BPPV diagnoses was 1.72 in the atypical BPPV
group and 1.36 in the typical BPPV group (p=0.310). The intensity of
nystagmus observed on the initial visit tended to be lower in atypical
BPPV compared to typical BPPV (atypical BPPV: right 4.4 deg/sec, left
4.5 deg/sec; typical BPPV: right 18.3 deg/sec, left 17.4 deg/sec).
Vitamin D levels were significantly lower in the atypical BPPV group
(19.17 ng/mL) compared to the typical BPPV group (32.70 ng/mL,
p<0.001). The number of CRT failures showed significantly higher
failure rates in the atypical BPPV group (2.84 vs. 0.14, p<0.001). The
duration from symptom onset to resolution was significantly longer in
the atypical BPPV group (30.07 days) compared to the typical BPPV
group (5.83 days, p=0.018). Until the last observation point (more
than five weeks after the first clinic visit), persistent nystagmus
was observed in 11 cases (44.0%) in the atypical BPPV group, despite
symptom resolution.
°á·Ð:Atypical BPPV is a refractory vestibular disorder with an unclear
pathophysiological mechanism. In this study, we observed that atypical
BPPV is associated with lower vitamin D levels, resistance to repeated
repositioning maneuvers, and a prolonged disease duration. |