| 발표형식 :
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접수번호 - 990158 OTOP 10-2 |
| THE IMPACT OF VITAMIN D DEFICIENCY AND OSTEOPOROSIS ON BENIGN
PAROXYSMAL POSITIONAL VERTIGO RECURRENCE: A POPULATION-BASED STUDY
FROM THE KOREAN NATIONAL HEALTH INSURANCE SERVICE |
| 1DEPARTMENT OF OTOLARYNGOLOGY-HEAD AND NECK SURGERY, ST. VINCENT’S HOSPITAL, COLLEGE OF MEDICINE, THE CATHOLIC UNIVERSITY OF KOREA, SEOUL, REPUBLIC OF KOREA 2 DEPARTMENT OF UROLOGY, SEOUL ST. MARY’S HOSPITAL, COLLEGE OF MEDICINE, THE CATHOLIC UNIVERSITY OF KOREA, 222, BANPO-DAERO, SEOCHO-GU, SEOUL, 06591, REPUBLIC OF KOREA 3DEPARTMENT OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, SEOUL ST. MARY’S HOSPITAL, COLLEGE OF MEDICINE, THE CATHOLIC UNIVERSITY OF KOREA, SEOUL, REPUBLIC OF KOREA 4DEPARTMENT OF OTOLARYNGOLOGY-HEAD AND NECK SURGERY, UIJEONGBU ST. MARY’S HOSPITAL, COLLEGE OF MEDICINE, THE CATHOLIC UNIVERSITY OF KOREA, SEOUL, REPUBLIC OF KOREA |
| SANGHYUN KWAK,
SANG HYUN KWAK1, YUN-HEE LEE2, JAE SANG HAN3, JI HYUNG LIM3, JAE-HYUN SEO3*, DONG-HEE LEE4*
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목적: Benign paroxysmal positional vertigo (BPPV) is a common vestibular
disorder characterized by brief episodes of vertigo triggered by
changes in head position, often associated with displaced otoconia in
the inner ear. Emerging evidence suggests that metabolic conditions,
such as vitamin D deficiency and osteoporosis, may increase the risk
of BPPV recurrence. This study investigates the association between
BPPV recurrence and these metabolic conditions using a large
population-based dataset. 방법:A nested case-control study was conducted using data from the Korean
National Health Insurance Service (NHIS) cohort, encompassing 507,744
individuals diagnosed with BPPV between 2005 and 2017. BPPV cases were
identified based on ICD-10-CM codes, vestibular function tests, and
canalith repositioning procedures. Multivariate analyses were performed
to assess the impact of vitamin D deficiency, osteoporosis, and
supplementation on BPPV recurrence. 결과:The mean age of participants was 52.36 ± 15.83 years, with females
constituting 68% of the cohort. Osteoporosis was present in 21.9%,
while calcium and vitamin D deficiencies were observed in 1.4% and
0.7% of participants, respectively. Vitamin D supplementation
significantly reduced the risk of BPPV recurrence (adjusted hazard
ratio [aHR]: 1.099, 95% CI: 1.003–1.203, p=0.042), with a more
pronounced effect in females (aHR: 1.110, 95% CI: 1.011–1.219,
p=0.0289). Age-related analysis showed reduced recurrence with
supplementation in middle-aged groups but less effect in those ≥70
years. Osteoporosis was strongly associated with higher recurrence
rates, particularly in females (HR: 1.38, 95% CI: 1.323–1.440,
p<0.0001). Combined calcium and vitamin D supplementation reduced
recurrence risk in younger women with osteoporosis (HR: 1.464, 95% CI:
1.030–2.082, p=0.0338). 결론:Vitamin D deficiency and osteoporosis are significant risk factors for
BPPV recurrence. Vitamin D supplementation reduces recurrence risk,
especially in females and younger individuals. Combined
supplementation of calcium and vitamin D may offer additional benefits
in reducing recurrence among patients with osteoporosis. These
findings support the role of metabolic health in BPPV pathophysiology
and recurrence prevention. |
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