¸ñÀû: Recent advancements in non-invasive neuromodulation therapies have
introduced Transcranial Electrical Stimulation (TES) as a promising
treatment for tinnitus. However, there is limited research on
transcranial random-noise stimulation (tRNS), whereby a weak
alternating current oscillating at random frequencies is delivered.
Therefore, this study aimed to investigate the clinical efficacy of
tRNS for alleviating chronic tinnitus symptoms. Additionally, the
study sought to objectively evaluate a home-based TES device's
clinical effectiveness and safety, which offers ease of use and
improved accessibility while achieving similar therapeutic effects. ¹æ¹ý:Sixty patients with chronic debilitating tinnitus with a Visual
Analogue Scale (VAS) distress score of 6 or more, unresponsive to over
three months of adequate pharmacological treatment, participated in
the study. The participants were randomly allocated into three groups:
20 in the active experimental group (A), 20 in the active control
group (B), and 20 in the placebo control group (C). Before treatment,
subjective tinnitus severity was assessed using a self-reported
tinnitus questionnaire (Tinnitus Handicap Inventory (THI), VAS
loudness (V-L), and VAS distress (V-D). After the clinical trial, the
same assessment was conducted to measure the degree of improvement in
subjective tinnitus symptoms. °á°ú:This study reported no major side effects after home-based tRNS
treatments. A Wilcoxon signed-rank test was conducted to examine the
differences between pre-treatment and post-treatment scores on V-L, V-
D, and THI for the active experimental group (A), active control group
(B), and placebo control group (C). The results showed that there was
no significant difference in V-D scores between pre-treatment and
post-treatment in the A group (p-value = 0.24), B group (p-value =
0.46), and C group (p-value = 0.18). Similarly, V-D and THI scores
analyses revealed no significant pre-post differences across all
groups (p-value > 0.05). These findings indicate that the expected
therapeutic effects were not observed in any groups.
A Friedman test was also used to analyze the differences in pre-
treatment VAS_loud, VAS_dist, and THI scores across the three groups.
The p-values for VAS_loud, VAS_dist, and THI scores were all greater
than 0.05, indicating that there were no statistically significant
differences in scores between the groups. This suggests no pre-
treatment score differences between the groups and confirms no
therapeutic effects were observed.
Regarding the pre-treatment scores, the active experimental group (A)
reported a mean VAS_loud score of 8.3, VAS_dist of 9.0, and a THI
score of 67.1. The active control group (B) had a mean VAS_loud score
of 7.7, VAS_dist of 8.3, and a THI score of 62.1. The placebo control
group (C) reported a mean VAS_loud score of 7.3, VAS_dist of 7.9, and
a THI score of 58.1. These baseline scores indicate varying levels of
tinnitus severity across the groups, yet no significant differences
were found upon treatment, suggesting that the intervention did not
result in a substantial therapeutic effect.
°á·Ð:This study evaluated the effectiveness and satisfaction of tinnitus
treatment using a home-based TES device. The results showed that the
active control group (B) had the highest average satisfaction, while
the active experimental group (A) had the lowest satisfaction.
Although this home-based tRNS treatment has been proven to be safely
applicable, the therapeutic benefits of the device may be limited.
Further studies with larger number of subjects are needed to refine
treatment protocols and explore more effective approaches. |