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EFFICACY OF NON-INVASIVE HOME-BASED TRANSCRANIAL RANDOM NOISE STIMULATION (TRNS) THERAPY IN PATIENTS WITH CHRONIC INTRACTABLE TINNITUS
DEPARTMENT OF OTORHINOLARYNGOLOGY–HEAD AND NECK SURGERY, SEOUL NATIONAL UNIVERSITY BUNDANG HOSPITAL, SEONGNAM, KOREA©ö, DEPARTMENT OF OTORHINOLARYNGOLOGY-HEAD AND NECK SURGERY, SEOUL NATIONAL UNIVERSITY HOSPITAL, SEOUL, KOREA©÷
JIWON CHOI, JIWON CHOI©ö, YOUN-JE CHOI©ö, JUN-HO LEE©÷, JAE-JIN SONG©ö
¸ñÀû: Recent advancements in non-invasive neuromodulation therapies have introduced Transcranial Electrical Stimulation (TES) as a promising treatment for tinnitus. However, there is limited research on transcranial random-noise stimulation (tRNS), whereby a weak alternating current oscillating at random frequencies is delivered. Therefore, this study aimed to investigate the clinical efficacy of tRNS for alleviating chronic tinnitus symptoms. Additionally, the study sought to objectively evaluate a home-based TES device's clinical effectiveness and safety, which offers ease of use and improved accessibility while achieving similar therapeutic effects. ¹æ¹ý:Sixty patients with chronic debilitating tinnitus with a Visual Analogue Scale (VAS) distress score of 6 or more, unresponsive to over three months of adequate pharmacological treatment, participated in the study. The participants were randomly allocated into three groups: 20 in the active experimental group (A), 20 in the active control group (B), and 20 in the placebo control group (C). Before treatment, subjective tinnitus severity was assessed using a self-reported tinnitus questionnaire (Tinnitus Handicap Inventory (THI), VAS loudness (V-L), and VAS distress (V-D). After the clinical trial, the same assessment was conducted to measure the degree of improvement in subjective tinnitus symptoms. °á°ú:This study reported no major side effects after home-based tRNS treatments. A Wilcoxon signed-rank test was conducted to examine the differences between pre-treatment and post-treatment scores on V-L, V- D, and THI for the active experimental group (A), active control group (B), and placebo control group (C). The results showed that there was no significant difference in V-D scores between pre-treatment and post-treatment in the A group (p-value = 0.24), B group (p-value = 0.46), and C group (p-value = 0.18). Similarly, V-D and THI scores analyses revealed no significant pre-post differences across all groups (p-value > 0.05). These findings indicate that the expected therapeutic effects were not observed in any groups. A Friedman test was also used to analyze the differences in pre- treatment VAS_loud, VAS_dist, and THI scores across the three groups. The p-values for VAS_loud, VAS_dist, and THI scores were all greater than 0.05, indicating that there were no statistically significant differences in scores between the groups. This suggests no pre- treatment score differences between the groups and confirms no therapeutic effects were observed. Regarding the pre-treatment scores, the active experimental group (A) reported a mean VAS_loud score of 8.3, VAS_dist of 9.0, and a THI score of 67.1. The active control group (B) had a mean VAS_loud score of 7.7, VAS_dist of 8.3, and a THI score of 62.1. The placebo control group (C) reported a mean VAS_loud score of 7.3, VAS_dist of 7.9, and a THI score of 58.1. These baseline scores indicate varying levels of tinnitus severity across the groups, yet no significant differences were found upon treatment, suggesting that the intervention did not result in a substantial therapeutic effect. °á·Ð:This study evaluated the effectiveness and satisfaction of tinnitus treatment using a home-based TES device. The results showed that the active control group (B) had the highest average satisfaction, while the active experimental group (A) had the lowest satisfaction. Although this home-based tRNS treatment has been proven to be safely applicable, the therapeutic benefits of the device may be limited. Further studies with larger number of subjects are needed to refine treatment protocols and explore more effective approaches.


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