목적: Balance disorders have been prominently studied through changes in the structural integrity of the vestibular system. Individuals that were experiencing difficulty in stabilization were discovered to lack hair cell architecture and functional neural connections that could absorb the stimulus effectively. One common cause of vestibular balance is through medication of antibiotics, particularly aminoglycosides, for inner ear treatments. 방법:This study focused on mimicking vestibular dysfunction brought about by aminoglycoside damage through administrating a nitrile-based compound, iminodipropionitrile. This model has been investigated as researchers can modify the intensity of the ototoxic compound which is parallel to the recovery time of the animal. As such, the study investigated the behavioral changes, morphological structure of the utricle, and evaluation of vestibular sensory evoked potentials of Sprague Dawley rats. 결과:We have seen evident changes in behavioral responses of animals after 7 days with its connection to the ablation of hair cells as well as neurofilament connections. Additionally, as hair cells were defunct, ribbon synapses were also reduced as animals continue to reduce balance starting at day 3. Vestibular sensory evoked potentials of animals showed variations between latency and amplitude as compared with baseline values and control animals without treatments as well. 결론:With such models, we can further evaluate determining causes of hair cell damage and effectively conduct proper treatment strategies on hair cell repair and regeneration.