| ¹ßÇ¥Çü½Ä :
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Á¢¼ö¹øÈ£ - 990101 RHOP 4-4 |
| ENDOSCOPIC MASS EXCISION FOR SINONASAL MALIGNANT TUMORS: SURGICAL
OUTCOMES FROM A SINGLE-CENTER OBSERVATIONAL STUDY |
| THE DEPARTMENT OF OTORHINOLARYNGOLOGY, SEOUL NATIONAL UNIVERSITY COLLEGE OF MEDICINE, SEOUL, KOREA |
| SIYEON JIN,
SIYEON JIN1, JEEYEON PARK1, WON JOON NOH1, SOO MIN KIM1, DOO HEE HAN1, TAE BIN WON1, DONG-YOUNG KIM1, HYUN JIK KIM1
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¸ñÀû: Malignant sinonasal tumors are rare and aggressive cancers often
presenting significant therapeutic challenges due to their proximity
to critical anatomical structures. Endoscopic surgery has emerged as a
promising alternative to traditional open approaches, but long-term
survival and recurrence outcomes remain inadequately studied. This
study aimed to evaluate the surgical outcomes, recurrence patterns,
and survival rates of patients with sinonasal malignancies treated via
endoscopic surgery over a 5-year period at a single tertiary care
center. ¹æ¹ý:A retrospective review of 75 patients with malignant sinonasal tumors
treated with surgery via endoscopic approach at Seoul National
University Hospital between 2018 and 2023 was conducted. Medical
records, endoscopic and radiologic images, and surgical videos were
analyzed. Disease-free survival (DFS) and overall survival (OS) were
analyzed using Kaplan-Meier curves. Associations between patient factors
and survival outcomes were assessed using Cox proportional hazards
regression and Chi-square tests. °á°ú:The mean DFS was 45.8 months (95% confidence interval: 38.7–52.8 months)
with a 5-year DFS rate of 50.8% (SE: ¡¾9.3%). The mean OS was
significantly longer at 125.6 months (95% confidence interval: 116.7–
134.6 months) with a 5-year OS rate of 92.2% (SE: ¡¾3.8%). Revision
surgeries had higher local recurrence rates (45.5%) than primary
surgeries (25%) but demonstrated longer DFS, likely influenced by
adjuvant treatments. Multivariate analysis revealed no statistically
significant predictors of recurrence or death. Recurrence rates and DFS
varied substantially among histological subtypes, while OS remained
uniform. °á·Ð:Endoscopic surgery for sinonasal malignancies demonstrates favorable
overall survival outcomes but poses challenges in achieving disease-
free survival, particularly in advanced-stage or recurrent cases. The
findings highlight the importance of multidisciplinary approaches and
adjuvant therapies to optimize outcomes. Further prospective, multi-
center studies are warranted to validate these results. |
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