학술대회 발표 연제 초록

발표형식 : 구연채택 접수번호 - 990065    RHOP 4-3 
RESPIRATORY EPITHELIAL ADENOMATOID HAMARTOMA: A RETROSPECTIVE ANALYSIS OF SUBGROUP CHARACTERISTICS
⒥DAVID GEFFEN SCHOOL OF MEDICINE, ²DEP. OF OTORHINOLARYNGOLOGY - HEAD AND NECK SURGERY, ⒧DEP. OF PATHOLOGY AND LABORATORY MEDICINE, UNIV. OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA
EUGENE OH, EUGENE OH^1, JAKOB L. FISCHER², DIPTI P. SAJED^3, JESSA E. MILLER², DANIEL M. BESWICK², JIVIANNE T. LEE², MARILENE B. WANG², JEFFREY D. SUH²
목적: Respiratory epithelial adenomatoid hamartoma (REAH) is rare, benign sinonasal lesion of unclear etiology, often involving the olfactory cleft (OC). This study aims to characterize REAH by comparing clinical differences between OC and extra-OC cases and analyzing patterns of OC REAH based on its presentation in isolation or with chronic rhinosinusitis (CRS). 방법:Retrospective review of pathology-confirmed REAH cases at a single institution (2009-2024). Patient charts and imaging were reviewed. 결과:88 patients with REAH were identified (mean 58.6+/-15.6 years, 58% male, and 75% white). Patients with REAH commonly presented with nasal obstruction (73.9%, n=65), postnasal drip (61.4%, n=54), hyposmia (60.2%, n=53), and rhinorrhea (55.7%, n=49). REAH was most frequently located in OC (55.7%, n=49). OC REAH patients were older (63.2 vs 52.8 years, p=0.003), had higher rates of allergies (67.3% vs 33.3%, p=0.002), asthma (55.1% vs 25.6%, p=0.005), hyposmia (69.4% vs 48.7%, p=0.049), and ear plugging (24.5% vs 2.56%, p=0.005). In contrast, patients with extra-OC REAH were more likely to have a reported history of sinus infections (43.6% vs 22.4%, p=0.034). Mean Lund-Mackay score was higher in OC REAH (11.6 vs 7.28, p=0.001). Among OC REAH, 67.3% were found incidentally in CRS, while 32.7% presented as isolated OC REAH with minimal sinus disease. CRS-associated REAH had higher asthma rates (66.7% vs 31.3%, p=0.019) and higher prevalence of hyposmia (78.8% vs 50%, p=0.04) than isolated OC REAH. On the other hand, epistaxis was more frequent in isolated OC REAH (25% vs 3.03%, p=0.034) compared to CRS-associated REAH. 결론:This study highlights key differences in REAH presentation based on location and CRS association. OC REAH was associated with older age, allergies, asthma, and hyposmia, while extra-OC REAH was linked to an increase incidence of sinus infections. CRS-associated REAH showed higher surgical burden and elevated Lund-Mackay scores. Isolated OC REAH was more often linked to epistaxis. Although REAH is benign, understanding its characteristics may aid in distinguishing it from other sinonasal lesions and managing coexisting conditions.


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