목적: This study aimed to investigate the influence of arterial hypertension (AH) on the manifestation of sensorineural hearing loss (SNHL) in the Kazakh population by analyzing the presence of specific genetic polymorphisms through whole-genome sequencing. 방법:A total of 1200 patients underwent whole-genome sequencing to identify genetic polymorphisms associated with SNHL using data from the GWAS database. Among the 320 polymorphisms associated with SNHL, 52 were genetically expressed in our patient cohort. Concurrently, all patients underwent comprehensive therapeutic and cardiological examinations, including assessment of hypertension severity, risk factors, medication usage, and laboratory test results. Audiological examinations were performed to confirm SNHL diagnosis. Patients were then divided into a case group (with AH and SNHL) and a control group (healthy individuals without AH and SNHL), with random assignment. 결과:Comparative analysis of the groups revealed a significantly higher prevalence of dominant and recessive polymorphisms associated with SNHL in the case group, with rates of 73% and 77%, respectively. In contrast, the control group exhibited these polymorphisms at lower rates of 27% and 23%. 결론:The findings suggest a strong association between arterial hypertension and the genetic predisposition to sensorineural hearing loss in the Kazakh population. The significantly higher prevalence of SNHL-related polymorphisms in hypertensive patients highlights the need for early audiological screening and targeted interventions in this high-risk group. Among the 52 identified polymorphisms, rs- 16864714, rs-1695, rs-17170356, rs-1878935, and rs-17287 were the most frequently expressed in our patients.