목적: Anxiety and depression are prevalent amongst patients with chronic rhinosinusitis (CRS) and associated with poorer outcomes following CRS treatment. However, the impact of CRS treatment on mental health remains uncertain. Therefore, this study seeks to evaluate if surgical intervention for CRS may alleviate comorbid depression and anxiety. 방법:PubMed, Embase, and Scopus databases were searched for cohort studies, cross-sectional studies, and randomised controlled trials relating to sinus surgery for CRS from inception to 30 April 2024 using the Population, Intervention, Comparison and Outcomes framework. Studies investigating levels of depression and anxiety pre- and post-surgical treatment of CRS were selected. 11 studies comprising 3,067 patients were included, of which 5 were quantitatively analysed. Data was extracted into a structured proforma and the Newcastle-Ottawa scale was used to evaluate study bias, following Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines and a PROSPERO- registered protocol (CRD42022351855). Meta-analyses of the ratio of means were conducted in a random-effects model. 결과:Sinus surgery was associated with significant improvement in markers of depression (ROM = 1.47, 95% CI = 1.03-2.10), anxiety (ROM = 1.10, 95% CI = 0.81 to 49) and quality-of-life. 결론:Sinus surgery for CRS may improve comorbid depression and anxiety.