목적: Candida auris, first detected in Japan in 2009 from ear discharge, presents significant challenges due to its extensive innate and acquired resistance to antifungal drugs. This pathogen has been implicated in hospital-acquired outbreaks and invasive infections in over 35 countries over the past decade, often associated with high mortality rates. In South Korea, C. auris is commonly isolated from ear discharges, underscoring the critical role of otolaryngologists in preventing its nosocomial transmission. This study aims to analyze the recent epidemiological trends of C. auris at a single center, with a particular focus on considerations for otolaryngology clinics. 방법:Patients with C. auris identified at Seoul St. Mary’s Hospital from January 2018 to December 2023 were enrolled. From the first reported case of complications due to C. auris infection in December 2021 at our hospital, we conducted a thorough investigation for all infection incidents, including source identification and tracking of infection routes. For cases occurring from January 2018 to December 2021, their medical records, including culture site, infection route, and clinical outcomes, were retrospectively reviewed. 결과:Over six years, C. auris was identified in 92 patients across 116 instances. From 2018 to 2022, the number of cases remained stable at 11- 17 annually, but sharply increased to 27 in 2023. Most identifications (105 cases, 90.5%) were from ear discharge, followed by peripheral blood (5 cases, 4.3%), catheters (4 cases, 3.4%), urine (1 case, 0.9%), and peritoneal fluid (1 case, 0.9%). Of the 92 patients, 89 (96%) had infections confined to the ear, and none of these progressed to invasive infection. However, among the three patients with infections in other sites, one died from candidemia, another is currently under ICU care, and the third recovered. 결론:While infections confined to the ear canal caused by C. auris did not progress invasively, candidemia resulting from C. auris can be fatal. Therefore, thorough disinfection of instruments used in outpatient clinics is essential to prevent nosocomial infections. Since C. auris is not eradicated by standard disinfectants, otolaryngology clinics should be equipped with disinfectants effective against C. auris.