목적: There is insufficient evidence to determine the effectiveness of treating allergic rhinitis by laser using a needle patch affixed to the skin as opposed to direct intranasal irradiation of nasal mucosa. We aimed to evaluate the effect of a needle patch laser with multiple wavelengths in an allergic rhinitis mouse model and its underlying mechanism. 방법:Balb/C mice were induced with ovalbumin (OVA) and alum. The needle patch laser was attached to the skin above the mouse's nasal cavity, transmitting light to the nasal mucosa. For 10 days, the needle patch laser administered simultaneous exposure to wavelengths of 670, 780, 850, and 910 nm. The exposures were conducted for either 10 or 20 minutes each day. Multiple allergic parameters were evaluated following the needle patch laser treatment. 결과:Needle patch laser treatment reduced allergic symptoms and inhibited total immunoglobulin E (IgE), OVA-specific IgE, IgG1, and IgG2 levels. Needle patch laser treatment also downregulated eosinophil infiltration and epithelium thickness of nasal mucosa along with cytokine levels IL-4 and IL-10. 결론:The light emitted by the needle patch laser, starting from the skin, demonstrated its ability to reach the nasal mucosa within the nasal cavity, suggesting potential for treating allergic rhinitis in mice and extending to clinical applications.