목적: Laryngopharyngeal reflux (LPR) has been identified as a contributing factor in patients experiencing post-thyroidectomy syndrome. The study aims to explore the correlation between thyroidectomy and LPR, assessing symptom changes pre-and post- surgery and conducting factor analysis to guide the management of LPR in thyroidectomy patients. 방법:In this prospective study, we enrolled a total of 88 patients who underwent thyroidectomy, either with or without central neck dissection (CND). All patients underwent comprehensive interviews focusing on dysphagia, voice disorders, throat discomfort, and symptoms associated with reflux. Additionally, laryngoscopy was performed during each visit. The Reflux Symptom Index (RSI) and Reflux Finding Score (RFS) were utilized for these assessments, conducted before thyroidectomy, as well as at 2 weeks and 3 months postoperatively. Patients were classified into groups based on preoperative evaluations and intraoperative findings, with each group defined by specific criteria. The trends in the scores of RSI and RFS changes were statistically analyzed for each categorized group. 결과:In the entire patient cohort, the RSI scores increased immediately following thyroidectomy but showed a slight decrease at 3 months postoperatively. The RFS scores exhibited a gradual increase up to 3 months after surgery. Additionally, in the analysis of individual items for the RSI and RFS, it was observed that the Hoarseness item in RSI, and both the Subglottic edema and Granulation items in RFS, showed a significant increase up to 3 months postoperatively. Subgroup analyses did not reveal significant differences in preoperative and postoperative RFS scores across groups, however, changes in RSI were significant in some subgroups. Patients without preoperative LPRD and those aged 50 years and above showed a significant increase in RSI scores up to 3 months postoperatively compared to the control group. Furthermore, at 2 weeks post-surgery, significant increases in RSI scores were observed in patient groups with a body mass index (BMI) less than 25, those who did not undergo CND, and those without external thyroid extension (ETE), compared to the control group. 결론:This study confirms a significant correlation between LPR and post-thyroidectomy syndrome. Marked discrepancies in RSI score trends on subgroup analysis highlight the necessity for detailed preoperative evaluations and consistent postoperative monitoring to pinpoint and address high-risk patients. Personalized postoperative interventions, informed by ongoing research on the pathophysiological relationship between thyroidectomy and LPR, are essential for improved management of LPR in patients undergoing thyroid surgery.