¸ñÀû: To evaluate the effect of vitamin D supplementation on the recurrence
rate of benign paroxysmal positional vertigo (BPPV). ¹æ¹ý:A single-center, prospective, double-blind, placebo-controlled,
parallel-group randomized controlled trial was conducted between
November 2018 and May 2020. After successful treatment with Canalith
repositioning maneuvers, patients diagnosed with BPPV were randomized to
either the vitamin D (n = 20) or placebo (n = 18) group. Only patients
with serum vitamin D levels <20 ng/mL were included. The vitamin D group
received 7,000 IU of vitamin D weekly for a year, while the placebo
group received a matching placebo drug. The final endpoint was the BPPV
recurrence rate and correlation with serum vitamin D levels after 6 and
12 months in both groups. °á°ú:Among 38 patients, 37 were followed up for 6 months and 30 for 12
months. At the 6-month follow-up, the vitamin D group had a
significantly higher serum vitamin D level than the placebo group (28.2
¡¾ 6.5 ng/mL vs 12.0 ¡¾ 4.8 ng/mL, p<0.001). This was also true after 1
year (29.4 ¡¾ 10.9 ng/mL vs 13.8 ¡¾ 3.7 ng/mL, p<0.001). The recurrence
rate was lower in the vitamin D group than in the placebo group after 6
months (5.0% vs. 28.7%, p=0.044) and 1 year (3.3% vs. 41.7%, p=0.008). °á·Ð:Vitamin D supplementation, in the absence of calcium, may be beneficial
for patients prone to recurrent BPPV episodes, particularly when serum
vitamin D levels are suboptimal. |