목적: Lidocaine, a local anesthetic, is known to possess anti-inflammatory properties. The present study aims to investigate the immunomodulatory effects of lidocaine analogs in a house dust mite (HDM)-induced allergic rhinitis (AR) mouse model. 방법:BALB/c mice were intraperitoneally sensitized and intranasally stimulated with HDM. From day 22 to 35, 10 & 100 ug/mL of compounds were intranasally administered 1 hour before HDM stimulation. Nasal symptoms, as well as serum total immunoglobulin (Ig) E levels, were measured. Interleukin (IL)-4, IL-10, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α levels in nasal lavage fluid (NLF) and their production by activated splenocytes were measured. Histological changes in the sinonasal mucosa were evaluated through hematoxylin and eosin and periodic acid-Schiff staining procedure. Th cytokines and their transcription factor mRNA expressions were determined using reverse-transcription polymerase chain reaction. 결과:Intranasal administration lidocaine analogs significantly suppressed allergic symptoms, serum IgE level, sinonasal mucosal inflammatory cell infiltration, and mucus-producing PAS positive cell count. Lidocaine analogs also significantly inhibited IL-4, IFN-r, and TNF-α production in splenocytes stimulated with HDM. Th1, Th2 and Treg related cytokines and their transcription factors mRNA in sinonasal mucosa were significantly suppressed through intransal lidocain analogs instillation. 결론:Repetitive intranasal instillation of lidocaine analogs showed anti- inflammatory and anti-allergic effects by suppressing nasal symptoms and inhibiting the production and expression of inflammatory mediators in the HDM-induced AR mouse model.