Objectives: To report a case of a Peripheral Ameloblastoma in a 36-year-old male. Methods: Case and Document Analysis Design: Case Report Setting: Tertiary Training Hospital Subject: One Result: A 36-year-old male presents with 10-year history developing an ulcerative buccal- mandibular mass, left, originating from an abrasion on buccal area, left caused brushing his teeth. Two histopathological examinations, years apart revealed ameloblastoma. Conclusion: This is a case of a 36year-old male afflicted with peripheral ameloblastoma accompanied by a possible neoplastic osseous invasion which has originated in the buccal mucosa. Early detection and complete excision with clear margins are the mainstays of treatment and could have prevented the disease from reaching this state, when it is destructive enough to disfigure the patient and alter the function of his jaw and cheeks.