¹ßÇ¥Çü½Ä :
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Á¢¼ö¹øÈ£ - 890542 RHPP-15 |
A Retrospective Study on the Effect of Immunotherapy on Nasal
Polyposis |
Univ. of South Florida Morsani College of Medicine1, Univ. of Louisville School of Medicine, Dep. of Otorhinolaryngology, Wolf and Yun P.S.C.2, Univ. of Louisville, Dept. of Anthropology3, Univ. of Louisville School of Medicine, Dept. of Otorhinolaryngology, James Graham Brown Cancer Center |
Johanna H. YUN,
Johanna H. YUN 1, Kiro J. YUN M.D. F.A.C.S.2, Christopher R. TILLQUIST Ph.D.3, Jeffrey M. BUMPOUS M.D. F.A.C.S.4
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¸ñÀû: This study hypothesizes that immunotherapy will predict longer time
intervals between polyp recurrences and will decrease the number of
revision surgeries. Patients using immunotherapy are predicted to
have higher CT scores prior to their first FESS. The presence of
eosinophils is also hypothesized to increase CT scores. ¹æ¹ý:From a 10-year span and minimum of 2 years of follow-up, patients
with a confirmed pathological report of nasal polyposis and
previous FESS by Dr. Kiro John Yun were included in the study. CT
scans taken prior to the first FESS were assigned a CT score,
based on the Lund-Mackay system. The presence of allergies,
asthma, aspirin hypersensitivity (ASA), and the use of
immunotherapy, montelukast and corticosteroids, were documented
then statistically analyzed in conjunction with time intervals
between polyp removals, and CT scores. °á°ú:The use of immunotherapy had no statistically significant effect on the number of revision surgeries or on the time to the recurrence of nasal polyps. Asthma and aspirin hypersensitivity had statistically significant correlations with higher CT scores. Eosinophilic presence in polyp tissue was not found to have any significant effect on the CT score. Increasing the CT score indicated a shorter time to a polyp recurrence. °á·Ð:It is recommended that patients seek removal of polyps at
earliest stages of disease to prevent revisions, chronic
symptoms, and financial investments. More prospective studies
need to determine any significant associations with immunotherapy
treatment and nasal polyposis recurrence and to verify the
effectiveness of this recommendation. |
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