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A Retrospective Study on the Effect of Immunotherapy on Nasal Polyposis
Univ. of South Florida Morsani College of Medicine1, Univ. of Louisville School of Medicine, Dep. of Otorhinolaryngology, Wolf and Yun P.S.C.2, Univ. of Louisville, Dept. of Anthropology3, Univ. of Louisville School of Medicine, Dept. of Otorhinolaryngology, James Graham Brown Cancer Center
Johanna H. YUN, Johanna H. YUN 1, Kiro J. YUN M.D. F.A.C.S.2, Christopher R. TILLQUIST Ph.D.3, Jeffrey M. BUMPOUS M.D. F.A.C.S.4
¸ñÀû: This study hypothesizes that immunotherapy will predict longer time intervals between polyp recurrences and will decrease the number of revision surgeries. Patients using immunotherapy are predicted to have higher CT scores prior to their first FESS. The presence of eosinophils is also hypothesized to increase CT scores. ¹æ¹ý:From a 10-year span and minimum of 2 years of follow-up, patients with a confirmed pathological report of nasal polyposis and previous FESS by Dr. Kiro John Yun were included in the study. CT scans taken prior to the first FESS were assigned a CT score, based on the Lund-Mackay system. The presence of allergies, asthma, aspirin hypersensitivity (ASA), and the use of immunotherapy, montelukast and corticosteroids, were documented then statistically analyzed in conjunction with time intervals between polyp removals, and CT scores. °á°ú:The use of immunotherapy had no statistically significant effect on the number of revision surgeries or on the time to the recurrence of nasal polyps. Asthma and aspirin hypersensitivity had statistically significant correlations with higher CT scores. Eosinophilic presence in polyp tissue was not found to have any significant effect on the CT score. Increasing the CT score indicated a shorter time to a polyp recurrence. °á·Ð:It is recommended that patients seek removal of polyps at earliest stages of disease to prevent revisions, chronic symptoms, and financial investments. More prospective studies need to determine any significant associations with immunotherapy treatment and nasal polyposis recurrence and to verify the effectiveness of this recommendation.


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