The most common non-epithelial origin of carcinoma of the head and neck region is mostly non-Hodgkin's lymphoma. More than 90% of all non-Hodgkin's lymphoma are B-cell lymphoma such as diffuse large B cell lymphoma and follicular lymphoma Mantle cell lymphoma is a subtype of B-cell lymphoma, belongs to a rare subtype of 5 to 7% of the total non-Hodgkin's lymphoma. Unlike Hodgkin lymphoma, Non hodgkin lymphoma commonly have extranodal organ involvement such as Waldeyer ring, salivary glands, thyroid gland. Only about 5% of primary extranodal non-Hodgkin's lymphoma are salivary gland origin. Treatment of mantle cell lymphoma has not been clearly established. But because of the high recurrence rate, chemoimmunotherapy has been selected as the primary treatment. We have experienced a Mantle cell lymphoma presenting as a mass in the tongue base and parotid, and report with a review of the literature.