목적: Lymph node metastasis and distant metastasis are important prognostic factors in laryngeal cancer. Fibrosis in primary tumor predisposes tumor progression and invasion. One of molecular markers related with fibrosis, lysyl oxidase (LOX) is an extracellular matrix-remodeling enzyme and regulates tumor invasion and metastasis. We investigated the prognostic significance of LOX expression in laryngeal cancer. 방법:The enrolled patients (N=100) underwent surgical treatment due to laryngeal cancer and had available specimen for tissue microarray. Upon immunohistochemistry, the proportion and intensity scores were measured and multiplied to get a total score. We defined LOX low group as low total score ( 4) and LOX high group as high total score LOX (> 4). We analyzed correlation between LOX expression and clinical factors as well as prognosis. 결과:LOX was predominantly expressed in cytoplasm or perinuclear area rather than peritumoral tissue. The Kaplan-Meier analysis showed that LOX high group had worse overall survival rate and disease free survival rate than LOX low group (p < 0.05). LOX expression was correlated with lymph node metastasis (p = 0.091). In the Cox regression analysis, LOX expression and lymph node metastasis were significant factors affecting overall survival rate (OR = 4.352, confidnece interval (CI) 1.512 - 12.522, p = 0.006 and OR = 2.337, CI 1.118 - 4.887, p = 0.024, respectively) and disease free survival rate (OR = 6.838, CI 1.611 - 29.031, p = 0.009 and OR = 2.483, CI 1.145 - 5.383, p = 0.021, respectively). 결론:High expression level of LOX is associated with lymph node or distant metastasis in larynx cancer and it predisposes poor prognosis in larynx cancer.