목적: Malnutrition and systemic lymphopenia are common in many cancers and is associated with tumor progression. This study aimed to investigate the prognostic value of nutritional and systemic inflammatory marker in patients with head and neck squamous cell carcinoma (HNSCC) 방법:This study included 156 patients with treatment-nave HNSCC who underwent definitive radiotherapy alone (n = 12) or chemoradiotherapy (n = 144). Body weight, and serologic and hematologic parameters were measured at both pretreatment and 2- month posttreatment. Univariate and multivariate analyses using Cox proportional hazards model were used to identify factors predictive of progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS). 결과:Three-year PFS, CSS, and OS were 82.7%, 96.1%, and 95.5%, respectively. The median follow-up was 37.4 months . Pretreatment hypoalbuminemia (<3.0 mg/dL), weight loss (>5 kg), low circulating neutrophil count (CNC), circulating monocyte count (CMC), and neutrophil-lymphocyte ratio (NLR) independently predicted lower PFS and OS by multivariate analyses (P<0.05). At 2-month posttreatment, weight loss (>10%), CNC, CMC and NLR decrease (>25%) from these pretreatment values also predicted lower PFS, CSS, and OS by multivariate analyses (P<0.05). 결론:Our data supports the evidence that several nutritional and systemic inflammatory markers are associated with early cancer progression in HNSCC