목적: A VAC device promotes wound healing by delivering negative pressure (a vacuum) at the wound site through a patented dressing, which helps draw wound edges together, remove infectious materials, and actively promote granulation at the cellular level.We report our experience with ten cases presenting an extended deep neck abscess involving the descending mediastinum, in which the application of a vacuum-assisted closure device was used instead of common drainage tubes after surgical evacuation. 방법:A total of 10 patients were diagnosed deep neck infection involving the descending mediastinitis. A contrast-enhanced computed tomography (CT) scan of the neck and thorax showed an extensive abscess of the neck space and mediastinum.The transcervical, intraoral or suprasternum Incisions were implemented appropriately. Wounds were irrigated with hydrogen peroxide, saline and diluted povidoneiodine solution. The therapy unit delivered a continuous negative pressure of 150200 mmHg. The VAC dressings were changed twice or three times a week by case. The criteria for VAC removal were, absence of fever, falling C-reactive protein levels and clinically healthy granulating wound. 결과:The majority of tissue cultures from mediastinitis patients showed Staphylococcus and Streptococcus. Three patients had positive cultures demonstrating Staphylococcus, three patients had streptococcus, two patients had Klebsiella, and one patients had Acintobacter. One patient had no growth in the tissue cultures yet. 결론:Of total 10 patients, 2 patients were expired on the treatment period, 6 patients were discharged with healthy granulating wound, and 2 patients were still going to treat with VAC in the hospital. These cases illustrate the possibility of avoiding more extensive and life-threatening procedures, such as open surgery, reduce intensive care stay and mortality. VAC is an effective method to treat deep neck infection involving the descending mediastinum.