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Á¢¼ö¹øÈ£ - 890357 HNOP-10 |
The Efficacy of 18F-FDG PET/CT Imaging for Extracapsular Spread of the Laryngeal Squamous Cell Carcinoma |
Dept. of Otorhinolaryngology-Head and neck Surgery, College of Medicine, The univ. of Catholic of Korea |
Byung-Joon CHUN,
Byung-Joo CHUN, Kwang-Jae CHO, Young-Hoon JOO, Sang-Yeon KIM, Min-Sik KIM
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¸ñÀû: The presence of extracapsular spread (ECS defined histopathologically as tumor penetration through the capsule of an involved lymph node) further decreases survival rates and increases the rates of regional recurrence and distant metastases. We evaluated the use of FDG PET/CT for the identification of extracapsular spread (ECS) with supporting histologic correlations in laryngeal cancer. ¹æ¹ý:We reviewed the medical records of 89 laryngeal cancer patients who underwent FDG PET/CT before surgery. The diagnostic evaluations at presentation included a complete physical examination, panendoscopy, CT and/or MRI scan of the head and neck, FDG PET/CT, chest radiography, and laboratory tests. CT and/or MRI scans were assessed to determine the regional lymph node status, while FDG PET/CT was used to identify regional and distant metastases °á°ú:ECS was present in 38.2% (18/47) of dissected necks and in 32.2% (20/62) of dissected cervical levels. There was a significant difference in the SUVmax between cervical lymph nodes with and without ECS (6.39 4.53 vs. 1.21 1.70, p < 0.001) the cutoff value for differentiating nodes with ECS from those without ECS was 2.8, with a sensitivity of 85.7% and specificity of 85.6%. °á·Ð:A median SUVmax cutoff value > 2.8 was associated with an increased risk of cervical lymph node metastasis and ECS in patients with laryngeal cancer. |
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