목적: The purpose of this study was to investigate the prognostic value of 18F-fluorodeoxyglucose positron emission tomography(FDG-PET) and to examine the predictive value of immunohistochemical markers hypoxia-inducible factor (HIF)-1a, carbonic anhydrase(CA)-IX, glucose transporter (GLUT)-1 for determining the optimal treatment modality for laryngeal carcinoma. 방법:A retrospective chart review was conducted between July 2012 and Jan 2015, and 50 patients who was diagnosed laryngeal carcinoma. FDG uptake at the primary tumor site and neck lymph nodes was measured using maximal standardized uptake value (SUVmax). Tissue samples from 50 laryngeal carcinomas were analyzed immunohistochemically for the expression of 3 markers. The KaplanMeier method, univariateand multivariate analyses, and the Cox proportional hazards model were used to analyze the associations between tumor characteristics and SUVmax and immunohistochemical results. 결과:High FDG uptake in main tumor and specifically neck mode is considered at increased risk of poor outcome, also associated with high GLUT-1 as immunohistochemical marker. However it is not related with HIF-1a, CA-IX and tumor TNM staging/size. 결론:Sometimes outcome of laryngeal cancer patients is not corresponded with TNM staging, tumor size with high SUVmax in FDG PET. Our results shows that high SUVmax is associated with high GLUT-1 level and poor outcome of laryngeal cancer patients. This showed that more aggressive multimodality treatment combinations were needed to laryngeal cancer patients with high SUVmax or high GLUT-1 level.