Milk-alkali syndrome (MAS) is a disorder featuring hypercalcemia, renal failure and metabolic alkalosis due to injestion of large amounts of calcium and absorbable alkali. MAS was first reported after Milk-alkali treatment of peptic ulcer in early 1910. But, Since the late 20th century, the wide availability and increasing consumption of calcium carbonate and vitamin D supplementation mostly for osteoporosis prevention has been noted as a reemerging clinical back grounds of MAS. We experienced a case of a woman who had took calcium and vitamin D for a year due to hypoparathyroidism after thyroidectomy. She was admitted suffering from nausea, vomiting, anorexia and irritability with the triad of hypercalcemia, metabolic alkalosis and acute renal insufficiency. Every abnormal symptoms, calcium level and renal function were normalized with fluid and diuretic therapies. Thus, otolaryngologist should know about Milk-alkali syndrome and pay attention to those who had a history of total thyroidectomy and hypoparathyroidism.