목적: Suture ligation to maintain hemostasis during surgery is a time- consuming and skill-intensive procedure. Energy based devices such as Harmonic scalpel or Ligasure have enabled more rapid and efficient methods for vessel and tissue ligation. Recently, lasers have been studied as the new surgical instrument for vessel sealing. The aim of this study is to investigate the safety and efficiency of vessel sealing system using 1470-nm diode laser. 방법:Femoral arteries (5mm diameter) were harvested from 40 kg female pigs and then the harvested artery was compressed with two glass slides to eliminate its luminal space. Subsequently, it was irradiated with 1470-nm diode laser. The sealing condition of vessel was evaluated according to laser power (5-30W), irradiation time (5 or 10 seconds), and focus mode (focus or defocus). The irradiated vessels were fixed in 4% formaldehyde and then processed to paraffin block. The paraffinized sample was sectioned and stained with H&E for histological evaluation. 결과:The tissue destruction of vessels was more severe in the group irradiated with focus mode. Additionally, the extent of damage was positively correlated to duration and power of laser beam. Among the various conditions of irradiation, the laser power between 15 and 20 W for 5 seconds was appropriate to seal the blood vessels. 결론:The adequate power and irradiation duration of laser can render blood vessels to be sealed effectively. Even if the relatively high power of laser was required, it may be possible to reduce the necessary power by modulating the compression condition of blood vessel.