Nasal septal perforation can occur by various causes such as trauma, surgery, inflammatory disease. In cases with symptoms, conservative management is considered at first. Surgical treatments are required for patients who do not respond to such treatments. Currently there is no standardized surgical technique and the surgical techniques are determined according to the location, size, or the surgeon’s preference. Techniques including primary closure, intranasal mucosal flap, and graft materials can be used alone or combined for operation. Though various autologous graft materials such as temporalis fascia, septal cartilage or conchal cartilage have been introduced, these have disadvantages of large surgical extent and long operation time. In order to compensate this, use of Allograft dermal matrix increases, however, lack of rigidity to support the septum can be problem. Here, we report a recent 49 year-old male patient with nasal septal perforation of which the reconstruction was successfully done implanting lyoplant and vomor together to compensate each other’s disadvantages and applying silastic sheet for mucosal regeneration.