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Clinical Features and Treatment Outcomes of Patients Aged under 20 who Diagnosed with Papillary Thyroid Carcinoma
Dept. of Otorhinolaryngology-Head & Neck Surgery, Korea Cancer Center Hos., Seoul, Korea
Sung-Ho PARK, Sung-Ho PARK, Guk Haeng LEE
¸ñÀû: Thyroid carcinoma rarely occurs in children and adolescents, whose clinical features are diverse, and treatment outcomes are still controversial. The aim of this study was to evaluate papillary thyroid carcinoma (PTC) patients with less than 20 year-old in the clinical features and the treatment outcomes ¹æ¹ý:This is a retrospective study for patients with younger than 20 years old, who were diagnosed as PTC from January 1992 to February 2009. Clinical features, sex, size, pathologic type, extrathyroidal extension, recurrence, multiplicity, extent of surgery, and lymph node metastasis were retrospectively evaluated. °á°ú:Total PTC patients with less than 20 years old were forty, and their mean age was 16 years old. Six patients were male, and thirty four patients were female. Median follow-up period was 109 months. In this study, the initial operations were total thyroidectomy for 9 patients, unilateral lobectomy for 15 patients, and total thyroidectomy and lateral neck dissection for 16 patients. Cervical lymph node metastases were diagnosed in 25 patients. Among these 25 patients, 16 patients showed lateral neck node metastases. Extrathyroidal extension was observed in 30 patients. Postoperative radioiodine ablation (RAI) was given to 35 patients. During follow-up period, 8 patients had recurred. Median recurrence interval was 72 months. Because of recurrence, 8 patients were performed additional operation and radioactive iodine therapy. All patients are alive at the present time. °á·Ð:Pediatric PTC is a rare disease and tends to present as advanced disease with low mortality compared to adult PTC. The majority of patients have lymph node metastases at central neck lymph node and lateral neck lymph node. Recurrence has no effect on survival. Aggressive treatment with total thyroidectomy, central neck dissection, and radioiodine therapy may prevent recurrence. Frequent follow up can help to detect recurrence early in young patients PTC.


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