목적: Although the role of the laryngopharyngeal reflux (LPR) in laryngeal disorder pathogenesis has been emphasized, limited data exist on the effect of postoperative anti-reflux medication in benign vocal fold lesion. The aim of this study was to determine the effect of a postoperative proton pump inhibitor (PPI) on voice outcomes after phonomicrosurgery. 방법:A total of 83 patients underwent phonomicrosurgery for benign vocal fold lesions. Voice handicap index (VHI) and perceptual and acoustic voice analysis were evaluated at baseline. After surgery, patients were randomized to the PPI group (lansoprazole 15mg twice daily for 2 months) and the non- PPI group. VHI and voice analysis were also performed at 2 months after surgery. 결과:Among 83 enrolled patients, a total of 59 patients (non PPI group n=30, PPI group n=29) completed the study. The VHI, perceptual and most acoustic parameters significantly improved in both groups after surgery. However, there was no significant difference in the percent of change in those parameters. When a sub-group analysis for patients with RSI >= 13 was performed, Jitter and Shimmer found significant improvement only in the PPI group. 결론:Postoperative PPI treatment did not significantly influence vocal recovery after surgery. However, postoperative PPI treatment appears to be beneficial for voice recovery after surgery in patients with suspected LPR.