목적: We aimed to analyze the therapeutic effect of zinc, lipoprostaglandin E1 in addition to systemic steroid therapy on hearing improvement for the treatment of idiopathic sudden hearing loss. 방법:Retrospective medical chart reviews of 500 patients with unilateral idiopathic sudden hearing loss between May 2006 and April 2014 were performed. Then, we conducted a multiple linear regression analysis using individual patients data. 결과:Better hearing gain was associated with low tone hearing loss (p<0.001), better initial contralateral hearing (p<0.001), absence of dizziness (p=0.015). Patients with intratympanic steroid treatment as salvage treatment showed lower hearing gain (p<0.001). Zinc supplementation was effective for the treatment of patients with mild hearing loss (p<0.001) On the contrary, significant improvement in hearing gain was found in patients with profound hearing loss who were treated with an additional lipoprostaglandin E1 (p<0.001). 결론:An Additional use of zinc and lipoprostaglandin E1 may enhance hearing improvement for treatment of idiopathic sudden hearing loss.