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Feasibility of an Implantable Miniature Surveillance System in Patients with Nasopharyngeal Cancer
Dept. of Otolaryngology National Univ. of Singapore
Chwee Ming LIM, Chwee Ming LIM
¸ñÀû: Early detection of recurrence in nasopharyngeal cancer (NPC) is pivotal for successful surgical salvage, which has been shown to improve survival. However, the challenge lies in having a reliable and accurate method of detecting early recurrence. In this study, we hypothesize that an implantable in-vivo miniature camera system in the nasopharynx will allow the identification of early morphologic features of NPC recurrence. Our aims are to design an implantable miniature camera system that is capable of automatic image transmission and to assess the feasibility of anchoring this system in a preclinical model. ¹æ¹ý:The feasibility study is first performed on a plastic skull model followed by a cadaveric model. Several key considerations of this development are 1) Anchoring device 2) Image quality. A prototype was first developed and tested in the plastic skull model before proceeding to a cadaveric model. This device was tested to investigate if it could be implanted onto the vomer bone and the articulation of the camera was tested. Additionally, the quality and range of capture of the nasopharynx were tested on the preclinical model. °á°ú:Our first prototype of the miniature surveillance system was developed based on a flexible camera module secured onto a movable shaft. Anchoring of this device was best achieved by securing it onto the vomer bone using 2 lag screws. At this position, the device was able to capture excellent wide-angle images. Due to the miniature size of the camera, the quality of the images is reasonable and reasonable definition of the anatomy could be appreciated. °á·Ð:Implanting a miniature surveillance camera is feasible by anchoring it on the posterior free edge of the vomer bone. Reasonable quality images were captured in our pre-clinical model. Further work is necessary to enhance the quality of the images and test the long-term durability of this in-vivo surveillance device.


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