목적: Allergic rhinitis (AR) is a global health problem affects patients from all ethnic group, socioeconomic condition and ages, although there is substantial evidence of the effectiveness of systemic immunotherapy (SIT), still controversy remained on the effect after SIT. A number of studies have evaluated about the efficacy of SIT in patients with allergic AR. But long term SIT and long term follow up studies are still insufficient. Our study is about the long term SIT & their efficacy through the follow up study. 방법:In 2004-2014, Total 76 patients who had recieved immunotherapy at Kyunghee medical allergy clinic due to AR were enrolled. We performed continuous administration of antigen with 3Mo. interval and analyzed results of 76 patients who received SIT for 5-10 yrs. In objective evaluation, we compared the result of MAST, eosinophil count. and in subjective evaluation, we measured the RQLQ scores change after immunotherapy. 결과:In MAST the average score of D. farinae was decreased from 3.92 0.28 to 3.50 1.17 there was significant change.(p=0.008). Also the average eosinophil count decreased significantly (p = 0.010) from 5.24 2.99 to 4.13 2.14. We also carried out the RQLQ to assess the patient's subjective symptoms. Compared to questionnaire before treatment, there was significantly improvement in overall categories. Especially, The improvements of average scores gap in nasal symptoms, 1.62 1.47 (p=0.000) and eye symptoms, 1.58 3.38 were high. 결론:We recognized that a long-term treatment of allergic immunotherapy was effective. So, Continuous SIT can be one of recommendable modality in treatment of AR with long term vision.