목적: The purpose of this study was to determine the 10-year cumulative incidence of hearing loss and its association with sex, underlying diseases, such as diabetes, hypertension and dyslipidemia, social history and inflammatory markers from blood test. 방법:Four hundred and seven subjects who took pure tone audiometry, routine laboratory test including inflammatory markers for regular health medication examination in both 2003 and 2013 in Ajou University Medical Center were included. The baseline demographic characteristics of the subjects were obtained by a questionnaire. Hearing thresholds were obtained by pure tone audiometry in each frequency of 500Hz, 1000Hz, 2000Hz, 4000Hz and 8000Hz. 'High-frequency hearing level' was defined as the average value of the hearing thresholds between 4000Hz and 8000Hz. 결과:In all frequency, the average hearing thresholds were elevated for 10-year-period. The difference was 5.60, 3.58, 7.53, 9.92, and 14.11dBHL in each frequency. There was no statistically significant correlation between the average hearing thresholds of all frequencies and sex, underlying diseases (diabetes, hypertension and dyslipidmedia), social history (smoking, alcohol consumption). But subjects who have smoking history showed statistically significant higher average of high-frequency hearing level thresholds. 결론:In all frequencies, the hearing threshold was elevated in this group between 2003 and 2013. Especially in high frequencies (4000Hz, 8000Hz), the hearing threshold was elevated more than other frequencies. There was a significant correlation between smoking history and the average high-freqeuncy hearing level threshold in this study.