목적: Nasal secretions include cytokines and inflammatory mediators which are involved in response to these pathogenic stimuli. We tried to find biomolecules which are involved in the pathogenesis of chronic rhinosinusitis. 방법:We collected nasal mucosal secretions from patients who were diagnosed as chronic sinusitis and underwent endoscopic sinus surgery. Total 63 nasal secretions were enrolled in our study, and medical records of these patients were reviewed. ELISA assay was performed to evaluate which biomolecules were associated with the severity of inflammation based on Lund Mackay score. Using normal human nasal epithelial cells, we performed Western blot and ELISA assay to evaluate that hypoxic condition and LPS treatment influenced on the secretion of biomolecule (HSP70). 결과:We found that the level of IL-8 and HSP70 were significantly associated with Lund Mackay score and IL-17C, CXCL10, and HSP27 were not. HSP70 was also significantly associated with the surgical outcome of enrolled patients. By Western blot and ELISA assay, we found that hypoxic condition induced the secretion of HSP70 significantly, and treatment with LPS mildly increased the secretion of HSP70. 결론:Our findings suggest that HSP70 is a well detected biomolecule in nasal secretions, and they are associated with the severity of inflammation and surgical outcomes. Hypoxic condition significantly increased the release of HSP70 into extracellular area, and we suggest that HSP70 might play a role in the pathogenesis of CRS.