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Mammary Analogue Secretory Carcinoma of the Salivary Gland in Parotid a Case Report
Dept. of Otolaryngology-Head and Neck Surgery, Chonnam National Univ. Medical School and Hwasun Hosp.
Seung Beom KIM, Joon Kyoo LEE, John Jae Woon LEE, Wan Seok CHO, Dong Hoon LEE, Tae Mi YOON, Sang Chul LIM
A new tumor entity of the salivary glands, mammary analogue secretory carcinoma (MASC) with ETV6-NTRK3 translocation, has recently been proposed. Histologically, the tumors have been reported to show a microcystic, papillary-cystic, glandular, or solid growth patterns, low-grade vascular nuclei, pale pink granular or vacuolated ¡°bubbly¡± cytoplasm, and intraluminal or intracellular secretions, featuring subtypes of acinic cell carcinoma. MASCs also mimic other salivary gland tumors, including adenocarcinoma, not otherwise specified (ANOS), mucoepidermoid carcinoma, and cystadenocarcinoma. A 15-year-old boy presented with infraauricular mass on the left side for eight months. FNA done outside the hospital suggested mucoepidermoid carcinoma. Partial parotidectomy was performed on the patient. About 4X3 cm sized black colored soft (somewhat cystic) mass arising at the tail of the left parotid gland occupying the space between SCM and Digastric Posterior Belly with adhesion into the medial surface of the SCM. Final pathology demonstrated MASC with extracapsular invasion and adjacent lymph node metastasis. Postoperative radiotherapy was recommended but his father refused the therapy.


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