Retropharyngeal hematoma is a rare condition. The etiology of a retropharyngeal hematoma includes infections, cervical spine trauma, great vessel trauma, and so on. Because this lesion has the possibility of compressing the potential airways, the rapid assessment and treatment are needed. This article discusses one case of retropharyngeal hematoma with a vacuum-assisted closure(VAC) device and highlights the utility of VAC in the management of retropharyngeal hematoma.