목적: The aim of the current study is to develop silk fibroin (SF)/polycaprolactone (PCL) hybrid scaffold via cold plate electrospinning technique as artificial dermis. 방법:We evaluated the physical, mechanical, and wound healing effect using scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FT-IR), CCK assay, and animal model. 결과:On structural analysis using SEM images and FTIR, these data showed that silk particles were successfully incorporated into PCL nanofibers. In addition, the SF/PCL hybrid nanofibers scaffold exhibited better cell viability, adhesion, and infiltration than the pristine PCL nanofibers scaffold. Moreover, we found that the SF/PCL nanofibers hybrid scaffold induced silmilar wound healing effect, smaller contraction area, and lesser scar formation compared with Matriderm®on animal study. 결론:Therefore, this preliminary study suggests that the SF/PCL hybrid scaffold may be a good promising biomaterial for artificial dermis.