| 발표형식 : 포스터(발표)
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접수번호 - 890011 RHPP-11 |
| Roles of ADAM10 and ADAM17 in Allergic Rhinitis |
| Dept. of Otorhinolaryngology-Head and Neck Surgery, Dong-A Univ., College of Medicine, Busan, Korea1, Dept. of Otorhinolaryngology-Head & Neck Surgery Inje Univ. Busan Paik Hosp.2 |
| Ji-Won SEO,
Jae-Hoon LEE1, Woo Yong BAE1, Ji-Won SEO1, Tae Kyung KOH1, Seong Kook PARK2
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목적: To assess the roles of ADAM 10 and ADAM 17 in allergic rhinitis by
assaying for expression of these materials. 방법:The expression of ADAM 10 and 17 was investigated in the allergic
nasal mucosa compared with non-allergic nasal mucosa. Tissue
samples were analyzed by real time polymerase chain reaction (PCR)
and Western blotting. 결과:The ADAM17 mRNA and protein levels were significantly lower in allergic nasal mucosa than in the non-allergic nasal mucosa (P < 0.05). The ADAM10 mRNA did not differ significantly between allergic nasal mucosa and non-allergic nasal mucosa. ADAM10 protein levels were significantly higher in the non-allergic nasal mucosa than in the allergic nasal mucosa (P < 0.05). 결론:Decreased ADAM17 and increased ADAM 10 expression can be
contributed to develop allergic rhinitis. We suggest that control
of ADAM 17 and ADAM10 may helpful to treat allergic rhinitis. |
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