목적: To date, there have been few reports on the antiadhesive effect of PUF as a middle ear packing. The purpose of this study was to investigate the antiadhesive effect of PUF soaked with saline in an animal model of mucosal trauma. 방법:Bioresorbable PUF soaked with saline was placed over abraded mucosa in the experimental group (n = 7), and compressed Gelfoam soaked with saline was placed in the control group (n = 7). After measurement of auditory brainstem responses (ABRs), the animals were sacrificed 3 weeks after packing placement for histological observation. HE stain, Masson-trichrome stain, and immunohistochemical stain for alpha-smooth muscle actin (SMA). 결과:The ABR results at postoperative week3 showed no statistically significant difference between the preoperative and post-packing values. An adhesion pattern withsubepithelial thickening was observed in the control group. Adhesion was not observed in the experimental group however,subepithelial fibrous thickening was noted. 결론:No significant subepithelial healing differences were found between Gelfoam and polyurethane foam (PUF).However, levels of hyperplasia of the mucosal lining and inflammation were lower with PUF packing. PUF packing is notfeasible as a middle ear packing material for abraded mucosa. Further studies are required before clinical application.